The ScreenMyGene Platform: Genetic Test Decision Support, End to End
Short answer: ScreenMyGene is genetic-test decision-support software that reads a clinical chart — typed notes, PDFs, or scanned records — and returns the genetic and pharmacogenomic panels the patient qualifies for, each anchored to a documented ICD-10-CM code, checked against CMS coverage policy, and screened through clinical safety gates. It is deterministic (same chart, same result), auditable, and built for molecular labs, medical directors, genetic counselors, and ordering clinicians.
What the platform does
Most genetic-test ordering fails at the seams: the indication is in the chart but not on the order, the panel is right but the diagnosis code is generic, the test is clinically sound but the payer's coverage policy was never checked. ScreenMyGene closes those seams in a single pass — ingest, extract, reason, validate, recommend — so an order leaves the platform defensible, not hopeful. The result: fewer avoidable denials, cleaner documentation, and specialist-grade test selection at the point of care.
Platform modules
Chart ingestion with OCR
Paste a note, upload a PDF or DOCX, or drop in a scanned requisition — optical character recognition lifts text from scanned records, and you review the extracted text before anything is analyzed. Batch mode processes up to five patients in one reviewable pass.
Clinical extraction and reasoning
A clinical language layer structures diagnoses, medications, family history, phenotype, and prior testing, then tiered rule engines map the chart to qualifying panels across 173 curated panels in five specialties: pharmacogenomics, hereditary cancer, neurology, inherited metabolic disease, and cardiogenetics.
CMS coverage reference, built in
The platform surfaces the governing Medicare policy alongside every recommendation — National Coverage Determinations plus LCDs and billing articles for Novitas Solutions (Jurisdictions H & L) and First Coast Service Options (Jurisdiction N) — with key billing and coverage alerts. See how these rules work in our guide to Medicare coverage for genetic testing.
Prior-testing verification
Medicare's once-in-a-lifetime rule for equivalent germline NGS testing is enforced at intake: the platform asks whether the patient has previously received equivalent testing and requires documented justification before a re-order proceeds.
Clinical trials and literature search
Integrated ClinicalTrials.gov and PubMed search puts recruiting trials and current molecular-genetics literature one click from the recommendation, so a qualifying patient can be matched to research options in the same workflow.
ENFD workflow
A dedicated module supporting epidermal nerve fiber density evaluation — extending neurology coverage into small-fiber neuropathy workups, where structured documentation and appropriate test sequencing matter for both clinical quality and coverage.
MME/ORT opioid-safety calculator
Morphine milligram equivalent calculation and Opioid Risk Tool scoring inside the analysis workspace, so opioid-exposure context sits beside pharmacogenomic drug–gene reasoning instead of in a separate tool.
Ask ScreenMyGene voice assistant
A hands-free assistant — in English or Spanish — answers questions like “show qualified panels” or “find trials for pancreatic cancer” without leaving the analysis.
History, export, and audit
Every analysis lands in a reviewable history with PDF export. Administrators manage user roles, module access, and a full audit log — because in clinical decision support, being able to show why matters as much as being right.
What makes it different
Deterministic. The same chart produces the same result every time — reproducible across a team and defensible on review. Transparent. Every panel shows the finding and the diagnosis code that produced it. Coverage-aware. Recommendations align to Medicare LCD/NCD and payer medical-necessity criteria from the start, not at the appeal stage. Safety-gated. Structural-cause, reversible-cause, and age constraints keep recommendations clinically appropriate.
Who uses it
Molecular and genomic laboratories triaging inbound orders; medical directors standardizing the basis behind every recommendation; genetic counselors accelerating chart review; ordering clinicians who need the right test without memorizing the genomic menu; and revenue-integrity teams that want coding-backed orders from the start.
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ScreenMyGene is clinical decision support intended to assist qualified healthcare professionals. It does not provide a diagnosis and does not replace independent clinical judgment; test-eligibility and coverage determinations remain with the ordering provider and applicable payer policy.