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Pharmacogenomics

Pharmacogenomic testing, matched to what the patient is actually taking.

Not every patient on a psychiatric or cardiovascular medication needs a PGx panel. ScreenMyGene reads the active medication list, matches it against established CPIC drug-gene interactions, and only surfaces a panel when a real, documented interaction risk exists.

ACTIVE MEDICATIONS CPIC PAIRS FOUND Clopidogrel Lisinopril Sertraline Metformin Atorvastatin Clopidogrel · CYP2C19 Sertraline · CYP2C19 Three medications carry no actionable drug–gene pair.
The medication list drives the match. Drugs without an actionable CPIC drug–gene pair stay dimmed — they do not qualify a panel on their own.

How it works for pharmacogenomics specifically

1. Medication list extraction — Active medications are pulled from the chart, including dose and indication where documented.

2. CPIC matching — Each medication is checked against CPIC drug-gene pairs. A panel only qualifies when there's a real interaction to evaluate.

3. Multi-gene panel logic — When multiple CPIC-relevant medications are present, ScreenMyGene surfaces the full panel that covers them.

4. ICD-10 and coverage check — The recommendation is anchored to a documented, matching diagnosis code and checked against Medicare LCD/NCD coverage policy.

NEVER A LONE GENE Single-gene order CYP2C19 Second interaction left unassessed. Multi-gene panel CYP2C19 CYP2D6 + more Covers every pair present One order. Nothing left hanging.
A lone CYP gene is never emitted as a standalone recommendation. With two interactions present, a single-gene order answers only one of them.

What this catches that manual review often misses

POLYPHARMACY, RESOLVED Drug A Drug B Drug C Gene 1 Gene 2 One panel spanning every gene the regimen implicates
In polypharmacy, drug–gene relationships overlap. The qualifying panel covers all of them in a single order.

Who this is for

See PGx panel selection in action.

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Why PGx ordering discipline pays in 2026

Genetic testing spend rose 35% year over year against 22% utilization growth, and payers are responding with tighter pharmacogenomic coverage review. Drug-first PGx ordering — panels qualified by documented CPIC-actionable exposures — is what keeps orders both clinically right and reimbursable. And where PGx meets opioid therapy, the built-in MME/ORT calculator puts morphine-milligram-equivalent and Opioid Risk Tool scoring beside the drug–gene reasoning.

35%YoY growth in genetic testing spend vs. 22% utilization — Avalon 2026 Lab Trend Report
100+drugs covered by CPIC gene–drug guidelines that anchor defensible PGx orders
MME/ORTopioid-safety scoring built into the same analysis workspace

Common questions

When does a PGx panel actually qualify?

When the patient is taking, or is a candidate for, medications with established CPIC gene-drug interactions - documented in the chart. Exposure-first logic is also what Medicare's PGx billing framework (article A58801) reimburses.

Why does ScreenMyGene never recommend a lone CYP gene?

Because polypharmacy patients usually carry multiple actionable interactions; a single-gene order answers one question and leaves the rest unassessed. The qualifying panel covers every documented pair in one order.

Does PGx testing expire?

No - germline genotype does not change. Results should be stored and reused across future prescribing decisions, which is why once-per-lifetime rules exist for equivalent tests.